In Tetris, the main objective is to pile blocks that will fall down continuously, in order to create a row or "line" without spaces. For this collection, the game comes with two bonus options: 2 PLAYER GAME (absent in the NES version) and VS. COM (absent in both versions), with 3 CPU opponents available, each one representing a difficulty level (EASY, MEDIUM, and HARD, respectively).

In Dr. Mario, the objective is to eliminate all the viruses contained in a big bottle. Dr. Mario (situated in the upper-right side of the screen) will throw capsules with 6 different color combinations (Red-Red, Red-Blue, Yellow-Yellow, Red-Yellow, Blue-Blue and Blue-Yellow) in order to line up at least four viruses or capsules of the same color horizontally or vertically and to make them disappear. In this compilation, the game comes with a bonus option: VS. COM, where you'll face the CPU players: Blue Virus (EASY), Yellow Virus (MEDIUM), and Red Virus (HARD).

For competitive players in both games, there is Mixed Match, where you and a friend can play Tetris and Dr. Mario like a tournament! Adjust the handicap levels, play time, music, and other settings to balance your different skills. The game order is: TETRIS B-TYPE (clear a certain amount of lines), DR. MARIO (disinfect a predetermined number of viruses) and TETRIS A-TYPE (clear lines until the time expires). At the end of the time limit, the player with the highest score is the winner.